Scientists engineer mosquito strain with malaria-blocking genes
Genes could spread through whole population in one season, researchers say
Scientists aiming to take the bite out of malaria have produced a strain of mosquitoes carrying genes that block its transmission, with the idea that they could breed with other members of their species in the wild and produce offspring that cannot spread the disease.
The researchers said on Monday they used gene-editing, a genetic engineering technique in which DNA can be inserted, replaced or deleted from a genome, on a species called Anopheles stephensi that spreads malaria in urban India.
They inserted DNA into the germ line, cells that pass on genes from generation to generation, of the species, creating
mosquitoes with genes that prevent malaria transmission by producing malaria-blocking antibodies. The genes are passed on to 99.5 per cent of offspring.
Malaria is caused by parasites transmitted to people through the bites of infected female mosquitoes. The goal is to release genetically modified mosquitoes to mate with wild mosquitoes so that their malaria-blocking genes enter the gene pool and eventually overrun the population, short-circuiting the species' ability to infect people with the parasites.
"It can spread through a population with great efficiency, increasing from 1 per cent to more than 99 per cent in 10
generations, or about one season for mosquitoes," University of California-San Diego biologist Valentino Gantz said.
University of California-San Diego biologist Ethan Bier called this a "potent tool in sustainable control of malaria,"
as all the mosquitoes in a given region would carry anti-malarial genes.
Won't eradicate malaria
"We do not propose that this strategy alone will eradicate malaria," University of California-Irvine molecular biologist
Anthony James said.
But in conjunction with treatment and preventive drugs, future vaccines, mosquito-blocking bed nets and eradication of
mosquito-breeding sites, it could play a major role in sustaining the elimination of malaria, James said.
Other scientists also have been working to create genetically engineered mosquitoes. One group last year said it created a strain carrying a gene leading nearly all offspring to be male, which could cause wild populations to plummet.
"In contrast, our much more flexible system only prevents mosquitoes from carrying malaria but can be used to do no harm to the mosquito. So it should generate the least amount of ecological damage," Bier said.
The UN World Health Organization estimates there will be 214 million cases of malaria worldwide in 2015 and 438,000
deaths, most in sub-Saharan Africa.
The research was published in the Proceedings of the National Academy of Sciences.